Cytoophidium assembly reflects upregulation of IMPDH activity
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چکیده
منابع مشابه
Cytoophidium assembly reflects upregulation of IMPDH activity
Cytidine triphosphate synthase (CTPS) and inosine monophosphate dehydrogenase (IMPDH) (both of which have two isoforms) can form fiber-like subcellular structures termed 'cytoophidia' under certain circumstances in mammalian cells. Although it has been shown that filamentation of CTPS downregulates its activity by disturbing conformational changes, the activity of IMPDH within cytoophidia is st...
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Several metabolic enzymes assemble into distinct intracellular structures in prokaryotes and eukaryotes suggesting an important functional role in cell physiology. The CTP-generating enzyme CTP synthase forms long filamentous structures termed cytoophidia in bacteria, yeast, fruit flies and human cells independent of its catalytic activity. However, the amino acid determinants for protein-prote...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2015
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.175265